Functional identity of hypothalamic melanocortin neurons depends on Tbx3
نویسندگان
چکیده
منابع مشابه
Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.
Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates. These neurons release POMC-encoded melanocortins, which are potent anorexigenic neuropeptides, and their absence from mice or humans leads to hyperphagia and severe obesity. Although the pathophysiology of hypo...
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15 صفحه اولDevelopment of the Hypothalamic Melanocortin System
The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R). Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developm...
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ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2019
ISSN: 2522-5812
DOI: 10.1038/s42255-018-0028-1